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DOI: 10.1055/s-0028-1100111
PHARMACOLOGY OF A NON–NITROGENOUS NEUTRAL PRINCIPLE ISOLATED FROM THE LEAVES OF ADHATODA VASICA
1 This paper is part of the thesis submitted to the degree of Ph, D. of the University of Bombay.Publication History
Publication Date:
15 January 2009 (online)
Summary
An alcoholic extract of the dried leaves of Adhatoda vasica Ne es was subjected to mild saponification with KOH. An ether extract of the saponified mixture yielded a white crystalline material, Vasakin. Vasakin is non–nitrogenous, neutral, and insoluble in water, melting at 273–274° G with decomposition. It blocks exogenous and endogenous acetyl choline, adrenaline, and has strong local anaesthetic activity. It inhibits salivary secretion induced by pilocarpine. It is not toxic in doses upto 1 g./kg. and does not affect behaviour or motor activity in experimental animals. It is less potent than atropine in cholinergic blocking activity.
Zusammenfassung
Aus den Blättern von Adhatoda vasica wurde eine stickstoffreie, auf Alkaloidteste negativ reagierende Substanz, die von den Autoren als Vasakin bezeichnet wird, isoliert und pharmakologisch getestet. Dabei zeigte sich weitgehende Ähnlichkeit mit den Eigenschaften des Atropins, allerdings ohne dessen zentrale Wirkungen. Untersuchungen zur Struktur des Vasakin sind im Gange.