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Planta Med 1975; 27(1): 72-76
DOI: 10.1055/s-0028-1097763
© Georg Thieme Verlag Stuttgart · New York

A POTENTIAL ANTILEUKEMIC SUBSTANCE PRESENT IN GLOBULARIA ALYPUM

G. Caldes, B. Prescott, J. R. King
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Publication Date:
14 January 2009 (online)

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Abstract

Extracts of ten medicinal plants from Greece were screened in vivo as potential antimalarial agents against Plasmodium berghei in infected mice, against lymphocytic leukemia P 388 in mice, and in vitro in KB neoplastic cell culture. They were also tested in vitro against Staphylococcus aureus ATCC 6538 P, and against Streptococcus faecium ATCC 19635.

None of the extracts screened showed any in vitro activity, nor any in vivo activity against Plasmodium berghei.

Aqueous extracts from one plant, Globularia alypum, which had been found to have significant activity against leukemia P 388, were analyzed for their chemical composition. The extracts contained a high concentration of carbohydrates, sugar alcohols, and phenolic compounds.

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