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Planta Med 1978; 33(2): 128-143
DOI: 10.1055/s-0028-1097367

© Georg Thieme Verlag Stuttgart · New York

Potential Anticancer Agents VIII.

Constituents of Baliospermum montanum (Euphorbiaceae)* Masaru Ogura, Kazuhiro Koike, Geoffrey A. Cordell, Norman R. Farnsworth
  • Department of Pharmacognosy and Pharmacology, College of Pharmacy, University of Illinois at the Medical Center, Chicago, Illinois 60612
* For Part VII see ref. [1].
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Publikationsdatum:
13. Januar 2009 (online)

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Abstract

An investigation of the constituents responsible for the antitumor activity observed for extracts of Baliospermum montanum roots has afforded five new phorbol ester derivatives exhibiting anticancer activity. Of these, montanin (1) was found to be closely related to huratoxin (6), and baliospermin (3) to mancinellin (14). Evidence for the structures of the other isolates, 12–deoxyphorbol 13–palmitate (2), 12–deoxy–5β–hy–dro–xyphorbol 13–myristate (4) and 12–deo–xy–16–hydroxyphorbol13–palmitate(5), was obtained by correlation with known compounds and preparation of derivatives.

Key Word Index

Baliospermum montanum - Euphorbiaceae - 12–Deoxyphorbol Derivatives - Anticancer

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