CC BY-NC-ND 4.0 · Endosc Int Open 2021; 09(04): E635-E636
DOI: 10.1055/a-1373-4825
Editorial

Sessile serrated lesions: Searching for the true prevalence

Charles J. Kahi
Indiana University School of Medicine, Indianapolis, Indiana, United States
,
Douglas K. Rex
Indiana University School of Medicine, Indianapolis, Indiana, United States
› Author Affiliations

Reality is merely an illusion, albeit a very persistent one – Albert Einstein

The serrated class of colorectal polyps includes hyperplastic polyps (HP), sessile serrated lesions (SSL), and traditional serrated adenomas (TSA). Among these, SSL are the most screening-relevant, because they are considered the main precursor lesion in the serrated colorectal cancer (CRC) pathway, and are much more prevalent than TSAs [1]. The growing recognition of the importance of SSLs has been accompanied by numerous studies reporting detection rates at colonoscopy. Inevitably, systematic reviews and meta-analyses have followed, reporting aggregates of available SSL detection studies. It is important here to distinguish between aspirational detection rates, which are more reflective of the true population-based SSL prevalence, and the more commonly reported overall SSL detection rates among groups of endoscopists.



Publication History

Article published online:
15 April 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Crockett SD, Nagtegaal ID. Terminology, molecular features, epidemiology, and management of serrated colorectal neoplasia. Gastroenterology 2019; 157: 949-966 e4
  • 2 Meester RGS, van Herk M, Lansdorp-Vogelaar I. et al. Prevalence and clinical features of sessile serrated polyps: a systematic review. Gastroenterology 2020; 159: 105-118 e25
  • 3 Hetzel JT, Huang CS, Coukos JA. et al. Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort. Am J Gastroenterol 2010; 105: 2656-2664
  • 4 Kahi CJ, Hewett DG, Norton DL. et al. Prevalence and variable detection of proximal colon serrated polyps during screening colonoscopy. Clin Gastroenterol Hepatol 2011; 9: 42-46
  • 5 de Wijkerslooth TR, Stoop EM, Bossuyt PM. et al. Differences in proximal serrated polyp detection among endoscopists are associated with variability in withdrawal time. Gastrointest Endosc 2013; 77: 617-623
  • 6 Abdeljawad K, Vemulapalli KC, Kahi CJ. et al. Sessile serrated polyp prevalence determined by a colonoscopist with a high lesion detection rate and an experienced pathologist. Gastrointest Endosc 2015; 81: 517-524
  • 7 IJspeert JGE, de Wit K, van der Vlugt M. et al. Prevalence, distribution and risk of sessile serrated adenomas/polyps at a center with a high adenoma detection rate and experienced pathologists. Endoscopy 2016; 48: 740-746
  • 8 WHO Classification of Tumours: digestive system tumours. 5th edition. Lyon: International Agency for Research on Cancer; 2019
  • 9 Corley DA, Levin TR, Doubeni CA. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med 2014; 370: 2541
  • 10 Kaminski MF, Regula J, Kraszewska E. et al. Quality indicators for colonoscopy and the risk of interval cancer. N Engl J Med 2010; 362: 1795-803