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Planta Med 2020; 86(12): 805-821
DOI: 10.1055/a-1196-1906
Biological and Pharmacological Activity
Reviews

A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity

Xiu-Qi Li‡
1   Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, Peopleʼs Republic of China
2   Graduate School of Chinese Academy of Agricultural Sciences, Beijing, China
,
Kuo Xu  ‡
1   Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, Peopleʼs Republic of China
,
Xin-Min Liu
1   Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, Peopleʼs Republic of China
,
Peng Zhang 
1   Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, Peopleʼs Republic of China
› Author AffiliationsSupported by: National Natural Science Foundation of China 31700295
Supported by: Agricultural Science and Technology Innovation Program of China ASTIP-TRIC05
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Abstract

Fungi are well known for their ability to synthesize secondary metabolites, which have proven to be a rich resource for exploring lead compounds with medicinal and/or agricultural importance. The genera Aspergillus, Penicillium, and Talaromyces are the most widely studied fungal groups, from which a plethora of bioactive metabolites have been characterized. However, relatively little attention has been paid to the genus Paecilomyces, which has been reported to possess great potential for its application as a biocontrol agent. Meanwhile, a wide structural array of metabolites with attractive bioactivities has been reported from this genus. This review attempts to provide a comprehensive overview of Paecilomyces species, with emphasis on the chemical diversity and relevant biological activities of these metabolic products. Herein, a total of 148 compounds and 80 references are cited in this review, which is expected to be beneficial for the development of medicines and agrochemicals in the near future.

Key words

Paecilomyces - secondary metabolites - chemical diversity - biological activity

Supporting Information

    Phylogenetic analyses of Paecilomyces species using ITS rDNA and β-tubulin genes are available as Supporting Information.

  • Supporting Information


Publication History

Received: 25 March 2020

Accepted after revision: 30 May 2020

Article published online:
09 July 2020

Georg Thieme Verlag KG
Stuttgart · New York

 

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